Overview
PART 1
Breast Cancer Risk Assessment Calculator - NCI
Mary
She is a 64-year-old woman in generally good health.
Ethnicity African American.
No history of any breast cancer or of ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) or has she received previous radiation therapy to the chest for treatment of Hodgkin lymphoma.
No mutation in either the BRCA1 or BRCA2 gene, or a diagnosis of a genetic syndrome.
She had her first child when she was 20.
She entered menopause at the age of 58.
Benign biopsy with atypical hyperplasia.
She has been on hormone replacement therapy since entering menopause (for the past six years).
She has gained some weight since menopause.
Her mother had breast cancer diagnosed at age 37.
She had her first period at 13.
ANSWER THE FOLLWOING QUESTIONS 1-4
5 year risk
Lifetime risk
Is her risk higher or lower than average women her age? Please provide rationale for your answer.
What are two factors that increase the risk for this patient?
PART 2
Breast Cancer Risk Assessment Calculator - NCI
Paula
She is 71 years of age, and currently has a urinary bladder tumor, with metastases in the ovaries and possible involvement of one lymph node.
No breast biopsies.
Ethnicity Asian American Chinese.
She had her first period at 13.
Paula’s sister was diagnosed with breast cancer three years ago, then ovarian cancer two-and-a-half years ago.
No history of any breast cancer or of ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) or has she received previous radiation therapy to the chest for treatment of Hodgkin lymphoma.
No mutation in either the BRCA1 or BRCA2 gene, or a diagnosis of a genetic syndrome.
Paula’s mother died of lung cancer.
Two maternal uncles had pancreatic cancer.
Her maternal aunt had myeloma.
Her maternal grandmother had uterine cancer.
No children.
ANSWER THE FOLLOWING QUESTION 5-8
5 year risk:
Lifetime risk:
Is her risk higher or lower than average women her age? Please provide rationale for your answer.
Utilize this resource to answer the question below:
https://www.cancer.org/cancer/types/breast-cancer/risk-and-prevention.html
What are two factors that increase the risk for this patient?
PART 3
Breast Cancer Risk Assessment Calculator - NCI
June is 58 years old.
Ethnicity White.
No history of any breast cancer or of ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) or has she received previous radiation therapy to the chest for treatment of Hodgkin lymphoma.
No mutation in either the BRCA1 or BRCA2 gene, or a diagnosis of a genetic syndrome.
She has been having mammograms every two or three years.
Two breast biopsies, none with typical hyperplasia.
Her first period was at age 11.
She has had two pregnancies resulting in two children, the first of which was at age 27.
She experienced menopause at age 51. She did not take hormone replacement therapy (HRT), but she used oral contraceptives for a total of four years in the past.
Her maternal aunt died of breast cancer in her 30’s.
Her mother died of a brain tumor at age 39.
ANSWER THE FOLLOWING QUESTIONS 9-12
5 year risk
Lifetime risk
Is her risk higher or lower than average women her age? Please provide rationale for your answer.
Utilize this resource to answer the question below:
https://www.cancer.org/cancer/types/breast-cancer/risk-and-prevention.html
What are two factors that increase the risk for this patient?
PART 4
Breast Cancer Risk Assessment Calculator - NCI
Nora
She is a 51-year-old, pre-menopausal woman.
Ethnicity American Indian.
No history of any breast cancer or of ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) or has she received previous radiation therapy to the chest for treatment of Hodgkin lymphoma.
No mutation in either the BRCA1 or BRCA2 gene, or a diagnosis of a genetic syndrome.
Her last bilateral mammogram showed no evidence of a mass.
No breast biopsies.
She had her first period at the age of 15.
She has had two pregnancies, each resulting in the birth of a child, the first of which was at age 32.
She used oral contraceptives for six years.
She has not taken any hormone-replacement therapy (HRT).
She smoked until age 26.
She consumes 1–4 alcoholic drinks per week.
Her mother had breast cancer at 48 years of age, and now has lymphoma (at age 72).
Her maternal grandmother had breast cancer at age 47, and died of lung cancer.
Her paternal first cousin currently has breast cancer.
Her paternal aunt died “at a young age” from breast cancer.
ANSWER THE FOLLOWING QUESTIONS 13-16
5 year risk
Lifetime risk
Is her risk higher or lower than average women her age? Please provide rationale for your answer.
Utilize this resource to answer the question below:
What are two factors that increase the risk for this patient?
PART 5
Using what you have learned from the patient case studies and the following resource, answer the questions below:
https://www.cancer.org/cancer/types/breast-cancer/risk-and-prevention.html
ANSWER THE FOLLOWING QUESTIONS
Give two examples of lifestyle-related risks:
Give two examples of risk factors you cannot change.
Give two examples that can reduce the risks of breast cancer.