In this project, you will explore a scientific research study recognized with prestigious awards such as the Nobel Prize or Lasker Prize. The project aims to enhance your understanding of cell signaling transduction processes and the ability to communicate scientific findings effectively.
You will select scientific research to explain the significance of the discoveries, the experimental methodologies employed, and the implications for our understanding of cell signaling transduction. Also, you will use Pubmed’s citation and publication count to analyze how this research impacted the field.
Please make sure the topic you choose is not on the topic you can choose to review
Then Choose two projects from below to review
Topic and Award Won |
|---|
2012 Gurdon, Yamanaka: stem cells, pluripotency. |
2015 Elledge, Witkin: DNA damage response |
Brenner, Horvitz, Sulston: programmed cell death (The Nobel Prize in Physiology or Medicine 2002) |
Nobel in Chemistry, 2008 Shimomura, Chalfie, Tsien: green fluorescent protein (GFP) |
Blackburn, Greider, Szosak: telomerase (Nobel 2009; Lasker 2006) |
2015 Lindahl, Modrich, Sancar: DNA repair |
Nobel Prize in Chemistry, 2022 Carolyn Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry” |
2007 Nobel Prizes in Physiology or Medicine Capecchi, Evans, Smithies: embryonic stem cells |
Katalin Karikó and Drew Weissman: Suppression of RNA Recognition by Toll-like Receptors (Nobel Prize in Physiology or Medicine 2023) |
2020 Nobel Prizes in Physiology or Medicine Charles M. Rice, Harvey J. Alter, and Michael Houghton; discoveries that led to the identification and characterization of the virus responsible for hepatitis C |
2021 Nobel Prize in physiology or medicine Receptors for temperature and touch David Julius and Ardem Patapoutain |
Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad won the 1998 Nobel Prize in Physiology or Medicine for their discovery that nitric oxide (NO) is a signaling molecule in the body. |
Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy” |
James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation” |
Alfred G. Gilman and Martin Rodbell "for their discovery of G-proteins and the role of these proteins in signal transduction in cells" (Nobel Prize in Physiology or Medicine, 1994) |
2008 Nobel Prize in Physiology or Medicine: Hausen: HPV cancer |
Bishop, J. M., & Varmus, H. E. (1979). Functions and origins of retroviral transforming genes. 1989 Nobel Prize in Physiology or Medicine & 1982 Lasker Award |
The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation" |
and please write which two you decide to review
Then:
Each of you must complete two drafts as checkpoint assignments that are part & parcel of the overall student project. These checkpoints are intended to ensure adequate progression and to provide a means for regular input from the instructor. Checkpoints are snapshots, and project creation is a work in progress. Students will likely adjust, modify, delete, and add content as they move forward. Submit this in the Canvas Assignment titled Checkpoint #3.
- PPTX draft that minimally includes completed Slides #1 & #2
- Working reference slide with all references-to-date
General Guidelines for the PowerPoint
You must create a PPTX file (all slides in landscape format). Use the following instructions:
- Slide #1 is the title slide. The following information must appear on this slide:
- Project Title
- Student Name
- Course Name
- Date
- Slides #2-8 are the content-based slides. Emphasis must be placed on originality in both thought & delivery. The presentation must include your critical evaluation of, or opinions about, the research, history, and future perspectives.
Specific Guidelines
Content Guidelines: each slide should focus on one of the following:
- Description of the foundational work that led up to the award
- Description of the award-winning work itself
- Explanation about how the research relates to, or can be integrated with, our core course material
- Critical evaluation of the work and explanation as to why you think the research was award-winning
- Impact of this award-winning work (on the larger field and subsequent research). You can use PubMed’s citation and publication count to analyze how this research impacted the field.
- Consideration of questions still at-large
- Contemplation about how one of these questions in #6 might best be answered; Where do you see this field going and how would you address this question? (for example: Can you target this for a therapeutic?, How could you enhance a technology?, Can you make a process more efficient?) *This should be slides 7&8.
Slide #9 is your references
Each of you will prepare a complete reference list for your project. This will be the last slide of the PowerPoint. Include any/all references used in creating the PPTX file. Select 5-10(+) different content-based sources when preparing your presentation, relying most heavily on articles and reviews from biological journals; this shall include a minimum of 4 peer-reviewed original research articles directly related to the prize-winning work. In addition, full citations for all images embedded into the PPTX must also be included in the references.
Organizational & Formatting Guidelines
- The presentation must be cohesive & well-organized.
- Each slide should focus on a distinct topic directly related to the overall project.
- Each content-based slide must include at least one informative image (figure, table, or illustration) that adds depth and clarity to the presentation. Images must be of sufficient size and resolution, as they will be the focal point for the content of each slide.
- Short citations for all images must be embedded within the slides themselves; if multiple images appear on one slide, assign all citations unambiguously. Use full citations, which must be listed in the references.
- The text should be kept to a minimum on the slides themselves; consider clarity versus clutter. Apply the 4x6 rule: 4 bullet points with a maximum of 6 words per bullet, or six (6) bullet points with a maximum of 4 words per bullet.
- As you formulate your slides, think carefully about the content you will deliver orally via Panopto.
Rubric
Research Project Checkpoint #3 Slides Draft [CST, 1 point]
| Criteria | Ratings | Pts |
|---|---|---|
This criterion is linked to a Learning OutcomeDraft of the PPTThe PPT includes information as requested in the checkpoint description. -Slides 1 and 2 follow the instructions -citation and reference list updated |