Overview
In this assignment, you will create a human pedigree detailing the inheritance of a genetic disease or disorder that is controlled by one gene in a dominant or recessive manner.
The pedigree must contain at least five generations and include examples of all the symbols associated with pedigree analysis, including non-afflicted, disease trait carriers and fully afflicted individuals, male and female members, marriage lines, sibling lines, and lines of descent, and both living and deceased familial members. Include a legend with a definition of each symbol. The pedigree must show at least one marriage event in each generation. Each generation, and each individual, must be numbered as is customary for authentic human pedigrees.
You can either use Shapes (circles, squares, and lines) in PowerPoint to create your pedigree, another graphics program you are familiar with, or you can draw the pedigree neatly by hand, take a picture and insert the picture into a PowerPoint slide. Another alternative is to record a video of you explaining the pedigree as you draw it! You cannot simply find an image of a pedigree online to use, you must create your own.
Use the pedigree that you created to explain the disease or disorder’s dominant or recessive inheritance pattern, and the autosomal or sex-linked inheritance pattern, including a discussion of phenotypes and homozygous/heterozygous genotypes. You should refer to at least three specific examples from your pedigree in your explanation of the inheritance pattern. Examples: “As seen in the first generation at the top of the chart, individual I-2 is a female with ____ phenotype, her likely genotype is _____ because ___” and “the male III-4 individual’s genotype must be ___ because of ____”).
After explaining the pedigree, you should briefly describe what is known about the gene and the allele causing the disease or disorder, including chromosome location.
Finally, you should describe the manifestations and clinical outcomes of the disease or disorder, explain how it is detected, and what, if anything, can be done to treat or alleviate the symptoms.
You are encouraged to include images on your slides that add to the information shared. Include the source below images; the name of the website and the link to that website.
See detailed requirements for the slides and narration below and in the grading rubric.
References to all information sources should be included in APA format on the last slide of the presentation, use in-text citations as needed:
APA 7th Edition Citation Examples: General Rules
If needed, review the Human Pedigree Analysis chapter assigned in Week 2.
You may find this video helpful as an additional resource:
Pedigrees | Classical genetics | High school biology | Khan Academy