Overview
- Explain what is meant by the phrase “the amino acid sequence determines the structure of the proteins”
- How is a protein domain defined and what is its significance?
- How do proteins evolve?
- What do proteins do?
- Why are beta pleated sheets and alpha helices so prevalent in proteins?
- Provide specific examples of how the structure of a protein determines or lends itself to the function of a protein
- Explain what stabilizes the structure of a protein
- In addition to alpha helices and beta sheets, proteins often contain regions that are intrinsically disordered. What functional roles do these regions play?
- How does protein structure govern protein function?
- What is allosterism and why is it important?
- How is the activity of proteins regulated?
- What is the significance of proteins forming large complexes that function as protein machines?
- Why are multienzyme complexes important?
- What are the general mechanisms of enzyme activity?
- What kinetic parameters are frequently used to characterize an enzyme?
- How do we describe the functionality of enzymes?
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