Overview
Discussion post requirements:
Each course participant is required to submit a minimum of two (2) posts for each discussion. Each post should be a substantive response (>300 words) to the question or questions included in the case study that provides an analysis of their interpretation of the scenario and which can be based upon external informational resources that can be accessed and that are relevant to the case.
Phenylketonuria Questions
- How would you justify the observation that that two different patients possessing the same mutation in the PAH enzyme may exhibit very different phenotypes with respect to PA metabolism?
- How can you explain the observation that in some individuals with a mutation to the PAH enzyme outside the BH4-binding site show a decrease in serum PA levels when given dietary BH4