ethical and legal + diagnosis of alzheimer’s disease

Overview

Hi,

We are a group of students doing a report and my part is about: ethical and legal + diagnosis of alzheimer’s disease

I need 400 words only ( no copy past, no AI ) as we will check for the plagiarize percentage before uploading the file. You must use the two sources below inly.

Diagnosis

The revised criteria by Jack et al. remain the gold standard — consider integrating recent biomarker-based diagnostic frameworks (e.g., 2023 NIA-AA AT(N) model). See above.

Add / Replace Suggestion:

✅ Add Jack et al., 2018 NIA-AA Research Framework (AT[N]) — essential landmark for biological definition.

✅ Add Jack et al., 2024 revised diagnostic criteria (Alzheimer’s & Dementia) — to reflect current diagnostic staging.

✅ Add van Dyck, C. H., et al. (2023). Lecanemab in early Alzheimer’s disease.

NJEM link

*New England Journal of Medicine*, 388(1), 9–21. https://doi.org/10.1056/NEJMoa2212948

Keep as Core:

1. Yakubu et al., 2024 (BMC Med Ethics) — systematic and relevant.

2. David et al., 2024 (Brain Communications) — excellent ethical practice focus.

3. Alazmi et al., 2020 (IJMDC) — relevant, though better placed under “Impact on HCPs”.

Add / Replace Suggestion:

Add Karlawish, J. (2021). “Ethical dilemmas in Alzheimer’s disease treatment and research.” NEJM.

✅ Include discussion of Aducanumab/Lecanemab approval ethics (NEJM 2021–2023 editorials).

NEJM Links

https://www.nejm.org/doi/full/10.1056/NEJMoa221294...

also, refer to the attached pictures.